Availability of 2025 Integrated Annual Report and Notice of Annual General Meeting Cilo Cybin Holdings Limited Incorporated in the Republic of South Africa (Registration number 2022/320351/06) Share code: CCC ISIN: ZAE000310397 ("Cilo Cybin" or "the Company") AVAILABILITY OF 2025 INTEGRATED ANNUAL REPORT AND NOTICE OF ANNUAL GENERAL MEETING INTEGRATED ANNUAL REPORT Shareholders are advised that the Integrated Annual Report of the Company for the year ended 31 March 2025, which incorporates, inter alia, a notice of Annual General Meeting, explanatory notes, the Company's remuneration policy and a form of proxy was distributed to Cilo Cybin shareholders today, Thursday, 31 July 2025. The complete set of audited consolidated financial statements (including the external auditor-, audit committee- and directors' reports for the year ended 31 March 2025), are all available on the Company' website www.cilocybin.com. NOTICE OF ANNUAL GENERAL MEETING Notice is hereby given to shareholders of Cilo Cybin that the Annual General Meeting ("AGM") of the Company will be held on Thursday, 11 September 2025 at 10:00 (SAST) in respect of the financial year ended 31 March 2025, entirely through electronic communication, to consider, and if deemed fit, pass with or without modification, the resolutions as set out in this notice. The Company has elected to convene and hold its AGM entirely by way of electronic communication in accordance with the provisions of section 63(2) of the Companies Act and the Listings Requirements of the JSE Limited (JSE) as read with clause 6.5 of the Company's Memorandum of Incorporation. The salient information pertaining to the AGM is set out below: Issuer name Cilo Cybin Holdings Limited Type of instrument Ordinary shares ISIN number ZAE000310397 JSE code CCC Meeting type Annual General Meeting Meeting venue Virtual Record date – To determine which shareholders are entitled to receive the Friday, 25 July 2025 Notice Publication/Posting Date Thursday, 31 July 2025 Last day to trade – Last day to trade to determine eligible shareholders that Tuesday, 2 September 2025 may attend, speak and vote at the AGM Record date – Record date to determine eligible shareholders that may attend, Friday, 5 September 2025 speak and vote at the AGM Meeting deadline date – (For administrative purposes), forms 10:00 on Tuesday, 9 September 2025 of proxy for the AGM to be lodged AGM date 10:00 on Thursday, 11 September 2025 Publication of results of AGM Friday, 12 September 2025 Website link www.cilocybin.com Centurion 31 July 2025 Designated Advisor Merchantec Capital Date: 31-07-2025 05:23:00 Produced by the JSE SENS Department. The SENS service is an information dissemination service administered by the JSE Limited ('JSE'). The JSE does not, whether expressly, tacitly or implicitly, represent, warrant or in any way guarantee the truth, accuracy or completeness of the information published on SENS. The JSE, their officers, employees and agents accept no liability for (or in respect of) any direct, indirect, incidental or consequential loss or damage of any kind or nature, howsoever arising, from the use of SENS or the use of, or reliance on, information disseminated through SENS.