Notification in terms of section 3.83(b) of the JSE Listings Requirements and section 122(3)(b) of the Companies Act Ascendis Health Limited (Registration number 2008/005856/06) (Incorporated in the Republic of South Africa) Share code: ASC ISIN: ZAE000185005 (“Ascendis Health” or “the Company”) NOTIFICATION IN TERMS OF SECTION 3.83(b) OF THE JSE LISTINGS REQUIREMENTS AND SECTION 122(3)(b) OF THE COMPANIES ACT In accordance with paragraph 3.83(b) of the Listings Requirements of the JSE Limited and section 122(3)(b) of the Companies Act 71 of 2008 (“the Act”), shareholders are advised of the following: In terms of section 122(1)(a) of the Act, Calibre Investment Holdings (Pty) Ltd (“Calibre”) has formally notified the Company that it now has acquired a beneficial interest in the ordinary shares of Ascendis Health, such that its total interest in Ascendis Health is 11.7%. As required in terms of section 122(3)(a) of the Act, upon receipt of the relevant Form TRP 121.1 from Calibre, the Company has filed the required notice with the Takeover Regulation Panel. The board of Ascendis Health (“the Board”) accepts responsibility for the information contained in this announcement as it pertains to Ascendis Health. To the best of the Board's knowledge and belief, the information contained in this announcement as it pertains to Ascendis Health is true and nothing has been omitted which is likely to affect the importance of such information. 9 September 2022 Bryanston Sponsor Questco Corporate Advisory Proprietary Limited Date: 09-09-2022 04:35:00 Produced by the JSE SENS Department. The SENS service is an information dissemination service administered by the JSE Limited ('JSE'). The JSE does not, whether expressly, tacitly or implicitly, represent, warrant or in any way guarantee the truth, accuracy or completeness of the information published on SENS. The JSE, their officers, employees and agents accept no liability for (or in respect of) any direct, indirect, incidental or consequential loss or damage of any kind or nature, howsoever arising, from the use of SENS or the use of, or reliance on, information disseminated through SENS.