Update on the Skin Disposal Ascendis Health Limited (Registration number 2008/005856/06) (Incorporated in the Republic of South Africa) Share code: ASC ISIN: ZAE000185005 (“Ascendis Health” or “the Company”) UPDATE ON THE SKIN DISPOSAL Shareholders of Ascendis Health (“Shareholders”) are referred to the announcement published on 1 February 2022 advising of, inter alia, the conclusion by Ascendis Health South Africa Proprietary Limited (“AHSA”) of a share sale agreement with Amka Products Proprietary Limited (“Amka”) in terms of which AHSA will dispose of the issued share capital in Ascendis Skin and Body Proprietary Limited, which operates the skin business unit comprising the Nimue business, to Amka (“Skin Disposal”). Shareholders are advised that AHSA and Amka have concluded an addendum to the share sale agreement, extending the closing date for the Skin Disposal to 31 May 2022. The Ascendis Health board of directors (the “Board”) accepts responsibility for the information contained in this announcement as it pertains to Ascendis Health. To the best of the Board's knowledge and belief, the information contained in this announcement as it pertains to Ascendis Health is true and nothing has been omitted which is likely to affect the importance of such information. 3 May 2022 Bryanston Sponsor Questco Corporate Advisory Proprietary Limited Date: 03-05-2022 12:35:00 Produced by the JSE SENS Department. The SENS service is an information dissemination service administered by the JSE Limited ('JSE'). The JSE does not, whether expressly, tacitly or implicitly, represent, warrant or in any way guarantee the truth, accuracy or completeness of the information published on SENS. The JSE, their officers, employees and agents accept no liability for (or in respect of) any direct, indirect, incidental or consequential loss or damage of any kind or nature, howsoever arising, from the use of SENS or the use of, or reliance on, information disseminated through SENS.