Disclosure of change in significant holding of Ascendis Health ordinary shares Ascendis Health Limited (Registration number 2008/005856/06) (Incorporated in the Republic of South Africa) Share code: ASC ISIN: ZAE000185005 (“Ascendis Health” or “the Company”) Disclosure of change in significant holding of Ascendis Health ordinary shares In accordance with paragraph 3.83(b) of the Listings Requirements of the JSE Limited and section 122(3)(b) of the Companies Act 71 of 2008 (“the Act”), shareholders are advised of the following: 1. Public Investment Corporation SOC Limited has formally notified the Company that, in terms of section 122(1) of the Act, it has disposed of a beneficial interest in the ordinary shares of Ascendis Health, such that its total remaining interest in Ascendis Health is 4.123%. 2. MIC Investment Holdings (Pty) Limited has formally notified the Company that, in terms of section 122(1) of the Act, it has disposed of a beneficial interest in the ordinary shares of Ascendis Health, such that its total remaining interest in Ascendis Health is 3.72%. As required in terms of section 122(3)(a) of the Act, the Company has filed the required notices with the Takeover Regulation Panel. 4 February 2021 Bryanston Sponsor Questco Corporate Advisory Proprietary Limited Date: 04-02-2021 04:00:00 Produced by the JSE SENS Department. The SENS service is an information dissemination service administered by the JSE Limited ('JSE'). The JSE does not, whether expressly, tacitly or implicitly, represent, warrant or in any way guarantee the truth, accuracy or completeness of the information published on SENS. The JSE, their officers, employees and agents accept no liability for (or in respect of) any direct, indirect, incidental or consequential loss or damage of any kind or nature, howsoever arising, from the use of SENS or the use of, or reliance on, information disseminated through SENS.