Trading Statement ASCENDIS HEALTH LIMITED (Incorporated in the Republic of South Africa) (Registration number 2008/005856/06) Share code: ASC ISIN: ZAE000185005 (“Ascendis” or “the Company”) TRADING STATEMENT In terms of paragraph 3.4(b) of the JSE Limited’s Listings Requirements, Ascendis shareholders are hereby advised that the Company’s financial results for the twelve months ended 30 June 2016 are expected to be more than a 20% change from the previous corresponding period. The table below illustrates the ranges anticipated against the comparative period: 12 months 12 months % increase/ ended ended (decrease) 30 June 2016 30 June 2015 Normalised Headline Earnings R325m – R336m R245m 33% – 37% Normalised Headline Earnings per share 116 – 121 cents 93 cents 25% – 30% (“NHEPS”) Basic Earnings R151m – R163m R210m (28)% – (22)% Basic Earnings per share (“EPS”) 54 – 59 cents 80 cents (33)% – (26)% Headline Earnings R147m – R158m R209m (30)% - (24)% Headline Earnings per share (“HEPS”) 52 – 57 cents 79 cents (34)% - (28)% Notes: 1. Normalised headline earnings comprise basic earnings adjusted for specific non-trading items and once-off costs. Once off costs amounted to c.R150m, representing c.2% of the purchase consideration of the Remedica and Scitec acquisitions as announced on SENS on 26 August 2016 (“Acquisitions”) and are mainly due to the transaction costs pertaining to these Acquisitions. The earnings of the Acquisitions will only be accounted for in the next financial year, which explains the discrepancy and subsequent decrease in basic and headline earnings as well as the EPS and HEPS. 2. NHEPS comprises normalised headline earnings per share adjusted for specific non-trading items and once off costs as indicated in point (1) above. 3. The “per share” measures reflect a lower percentage increase than the earnings numbers due to the change in weighted average number of shares of c.5m being an increase of c.2%, due to additional shares issued by Ascendis during the course of the twelve month period. The financial information on which this trading statement is based has not been reviewed or reported on by the Company’s auditors. Shareholders are advised that the results for the twelve months ended 30 June 2016 are scheduled to be released on SENS on 14 September 2016 and presented in Johannesburg on 14 September 2016 and Cape Town on 15 September 2016. 7 September 2016 Johannesburg Sponsor Investec Bank Limited Date: 07/09/2016 07:30:00 Produced by the JSE SENS Department. The SENS service is an information dissemination service administered by the JSE Limited ('JSE'). The JSE does not, whether expressly, tacitly or implicitly, represent, warrant or in any way guarantee the truth, accuracy or completeness of the information published on SENS. The JSE, their officers, employees and agents accept no liability for (or in respect of) any direct, indirect, incidental or consequential loss or damage of any kind or nature, howsoever arising, from the use of SENS or the use of, or reliance on, information disseminated through SENS.