Dealings in securities by directors ASCENDIS HEALTH LIMITED (Incorporated in the Republic of South Africa) (Registration number 2008/005856/06) ISIN: ZAE000185005 Share code: ASC (“Ascendis”) Dealings in securities by directors In terms of paragraphs 3.63 to 3.65 of the JSE Limited (“the JSE”) Listings Requirements ("the Listings Requirements"), the following information, relating to dealings in securities by directors, is disclosed: Directors: Gary Shayne and Crispian Dillon Nature of the transaction: As a consequence of their indirect beneficial interest in Ascendis held through Coast2Coast Investments Proprietary Limited (“C2C”), in which Gary Shayne has an 85% indirect beneficial interest and Crispian Dillon has a 15% indirect beneficial interest, certain option agreements pertaining to Ascendis acquisitions (“Acquisitions”) are required to be disclosed as dealings in securities by these directors. In some Acquisitions a portion of the total purchase consideration is settled by way of Ascendis ordinary shares (“Ascendis Shares”). In order to provide the acquired companies’ vendors (“Vendors”) with the required certainty regarding the rand value of the Ascendis Shares, C2C entered into an arm’s length option agreement (“Option Agreement”) directly with the Vendors. Shareholders are referred to the SENS announcements dated 6 March 2014 relating to an Option Agreement, whereby C2C granted the Vendors a put option and the Vendors granted C2C a call option over the Ascendis Shares which were issued in part settlement of the purchase consideration (“Option Shares”). The exercise date over 50% of the Option Shares is between 31 March 2016 and 30 April 2016. The Vendors have elected to exercise their options in terms of the Option Agreement. The Option Agreement is a historical arm’s length transaction that stipulates the predetermined strike prices, exercise dates and exercise rights of the parties. As such the directors have no discretion over the timing or price of the Vendors’ rights to exercise under the Option Agreement. Total number of Shares: 909 091 Exercise price per share R18.45558 Total transaction value R16,777,801 Date of transaction 18 April 2016 Class of shares Ordinary Shares Transaction type Purchase, off market Extent of interest: Indirect beneficial, through Gane Holdings, in which Gary Shayne has an 85% indirect beneficial interest and Crispian Dillon has a 15% indirect beneficial interest. Written clearance obtained: Clearance was obtained from the Chairman. 19 April 2016 Johannesburg Sponsor Investec Bank Limited Date: 19/04/2016 08:30:00 Produced by the JSE SENS Department. The SENS service is an information dissemination service administered by the JSE Limited ('JSE'). The JSE does not, whether expressly, tacitly or implicitly, represent, warrant or in any way guarantee the truth, accuracy or completeness of the information published on SENS. The JSE, their officers, employees and agents accept no liability for (or in respect of) any direct, indirect, incidental or consequential loss or damage of any kind or nature, howsoever arising, from the use of SENS or the use of, or reliance on, information disseminated through SENS.