Dealings in securities by directors ASCENDIS HEALTH LIMITED (Incorporated in the Republic of South Africa) (Registration number 2008/005856/06) ISIN: ZAE000185005 Share code: ASC (“Ascendis”) Dealings in securities by directors In terms of paragraphs 3.63 to 3.65 of the JSE Limited Listings Requirements the following information, relating to dealings in securities by directors, is disclosed: Directors: Gary Shayne and Crispian Dillon Nature of the transaction: As a consequence of their indirect beneficial interest in Ascendis held through Gane Holdings Proprietary Limited (“Gane Holdings”), in which Gary Shayne has an 85% indirect beneficial interest and Crispian Dillon has a 15% indirect beneficial interest, certain option agreements pertaining to Ascendis acquisitions are required to be disclosed as dealings in securities by these directors. Prior to the listing of Ascendis on 22 November 2013 (“Listing”), Ascendis acquired a company (“Acquired Company”) on the basis that a portion of the total purchase consideration is settled by way of Ascendis ordinary shares (“Ascendis Shares”) on a deferred basis. In order to provide the vendors of the Acquired Company (“Vendors”) with the required certainty regarding the rand value of the listed Ascendis Shares at the future negotiated date, Gane Holdings entered into a separate arms length option agreement (“Option Agreement”) directly with the Vendors. This Option Agreement provides the Vendors with a guaranteed return in the form of an agreed amount which is settled by Gane Holdings. No fees are payable by Ascendis to Gane Holdings for this agreement and there are no financial implications for Ascendis as a result of this agreement. Total number of Shares: 927 272 Value per share R35.50 which is calculated in terms of the formula contained in the Option Agreement, and to be settled in full on or about 30 June 2018 Total transaction value R 32 920 741 Date of transaction 10 March 2016 Class of shares Ordinary Shares Transaction type Purchase, off market Extent of interest: Indirect beneficial, through Gane Holdings, in which Gary Shayne has an 85% indirect beneficial interest and Crispian Dillon has a 15% indirect beneficial interest. Written clearance obtained: Clearance was obtained from the Chairman. 10 March 2016 Johannesburg Sponsor Investec Bank Limited Date: 10/03/2016 05:15:00 Produced by the JSE SENS Department. The SENS service is an information dissemination service administered by the JSE Limited ('JSE'). The JSE does not, whether expressly, tacitly or implicitly, represent, warrant or in any way guarantee the truth, accuracy or completeness of the information published on SENS. The JSE, their officers, employees and agents accept no liability for (or in respect of) any direct, indirect, incidental or consequential loss or damage of any kind or nature, howsoever arising, from the use of SENS or the use of, or reliance on, information disseminated through SENS.