Exemption from the Takeover Regulation Panel Adcock Ingram Holdings Limited (Incorporated in the Republic of South Africa) Registration number 2007/016236/06 Share code: AIP ISIN: ZAE000123436 (“Adcock Ingram”) CFR Pharmaceuticals S.A. (Incorporated in the Republic of Chile) Chilean Tax ID: 76.116.242-K Securities Regulation Chilean Registry number: 1067 Share Code on the Santiago Stock Exchange: CFR ISIN: CL0001762831 (“CFR”) EXEMPTION FROM THE TAKEOVER REGULATION PANEL (“TRP”) AND CONFIRMATION THAT THE TERMINATION AGREEMENT CONCLUDED ON 7 FEBRUARY 2014(“TERMINATION AGREEMENT”) IS NOW EFFECTIVE Adcock Ingram shareholders are referred to the joint announcement released on the Stock Exchange News Service of the JSE Limited by Adcock Ingram and CFR (“the Parties”) on Friday, 7 February 2014, advising that the Parties had entered into a Termination Agreement providing for the consensual termination of the Transaction Implementation Agreement concluded between the Parties on 11 September 2013, as amended (“TIA”)and the termination of the scheme of arrangement proposed between Adcock Ingram and the holders of Adcock Ingram ordinary shares (other than the holder of treasury shares) in relation to the CFR offer (“Scheme”). In terms of the Termination Agreement, the termination of the TIA and the Scheme was conditional upon receipt of written exemption from the TRP from, among other things, the application of regulation 101 (2) of the Companies Regulations, 2011. Adcock Ingram shareholders are advised that CFR has now received the requisite exemption from the TRP and, accordingly, the Termination Agreement is now effective. For Adcock Ingram media enquiries: Brunswick Carol Roos +27 72 690 1230 Marina Bidoli +27 83 253 0478 For CFR media enquiries Mark Garraway +27 82 610 1226 Midrand 13 February 2014 Financial Adviser and Sponsor to Adcock Ingram Deutsche Bank Legal Adviser to Adcock Ingram in South Africa Read Hope Phillips Attorneys Public Relations Adviser to Adcock Ingram Brunswick Financial Adviser to CFR Credit Suisse Legal Adviser to CFR in South Africa Bowman Gilfillan Inc. Legal Adviser to CFR in Chile Honorato Russi & Eguiguren Limitada Date: 13/02/2014 02:04:00 Produced by the JSE SENS Department. The SENS service is an information dissemination service administered by the JSE Limited ('JSE'). The JSE does not, whether expressly, tacitly or implicitly, represent, warrant or in any way guarantee the truth, accuracy or completeness of the information published on SENS. The JSE, their officers, employees and agents accept no liability for (or in respect of) any direct, indirect, incidental or consequential loss or damage of any kind or nature, howsoever arising, from the use of SENS or the use of, or reliance on, information disseminated through SENS.