Renewal of cautionary annuncement Adcock Ingram Holdings Limited (Incorporated in the Republic of South Africa) Registration number 2007/016236/06 Share code: AIP ISIN: ZAE000123436 (“Adcock Ingram” or “the Company”) RENEWAL OF CAUTIONARY ANNOUNCEMENT Shareholders are referred to the announcement dated 3 July 2013 in which the independent board of directors of Adcock Ingram (“Independent Board”) notified Adcock Ingram shareholders that the Company had entered into discussions with CFR Pharmaceuticals S.A. (“CFR”) regarding a non-binding offer that could lead to CFR making a cash and shares offer to acquire 100% of the issued share capital of Adcock Ingram, excluding treasury shares, by way of a scheme of arrangement (“the Potential Offer”). Shareholders are advised that discussions with CFR regarding the Potential Offer are ongoing. Whilst there is still no certainty that a firm offer will either be proposed or implemented, the Independent Board continues to engage exclusively with CFR with a view to a firm offer being made to Adcock Ingram shareholders by way of a scheme of arrangement. The full details of the Potential Offer will be communicated to Adcock Ingram shareholders and the market if and when a firm offer is made by CFR. The Independent Board has noted recent speculation regarding the Company. Subsequent to the Company entering into exclusive discussions with CFR, the Independent Board has received further unsolicited proposals from potential offerors, each of which contemplates a scheme of arrangement and therefore the co-operation of the Independent Board. The Independent Board must evaluate any bona fide proposal submitted to the Company that could maximise value for Adcock Ingram shareholders and promote the interests of the Company. In this regard, the Independent Board confirms that it has not received any proposal that it at present regards as being more favourable than the Potential Offer. The Independent Board is conscious of its legal and regulatory obligations not to publish misleading information nor information that may give rise to uncertainty and affect the integrity of the marketplace to the detriment of Adcock Ingram shareholders. Accordingly, the Independent Board does not intend to publish the details of every proposal it receives. The Potential Offer may have a material effect on the price of the Company’s securities. Accordingly shareholders are advised to continue exercising caution when dealing in the Company’s securities until a further announcement is made. For media enquiries: Brunswick Tel: +27 11 502 7300 Carol Roos +27 72 690 1230 Marina Bidoli +27 83 253 0478 Midrand 15 August 2013 Sponsor to Adcock Ingram Deutsche Securities (SA) Proprietary Limited Date: 15/08/2013 12:00:00 Produced by the JSE SENS Department. The SENS service is an information dissemination service administered by the JSE Limited ('JSE'). The JSE does not, whether expressly, tacitly or implicitly, represent, warrant or in any way guarantee the truth, accuracy or completeness of the information published on SENS. The JSE, their officers, employees and agents accept no liability for (or in respect of) any direct, indirect, incidental or consequential loss or damage of any kind or nature, howsoever arising, from the use of SENS or the use of, or reliance on, information disseminated through SENS.