Cautionary Announcement ASPEN PHARMACARE HOLDINGS LIMITED (Incorporated in the Republic of South Africa) Registration number 1985/0002935/06 Share code: APN ISIN: ZAE000066692 ("Aspen" or "the Company") CAUTIONARY ANNOUNCEMENT Shareholders are advised that Aspen and Aspen Global Incorporated (“AGI” - a wholly owned subsidiary of Aspen) are currently engaged in discussions with GlaxoSmithKline plc (“GSK”) in respect of a possible transaction. Aspen and AGI have made a combined offer to GSK in terms whereof: • AGI will acquire from GSK the Arixtra and Fraxiparine/Fraxodi brands (“the Brands”) and business worldwide, except in China, Pakistan and India - these Brands generated approximately £420 million in revenue for GSK in its 2012 financial year ended 31 December 2012. The Brands would transfer to AGI at the end of 2013; and • Aspen will acquire from GSK a specialised sterile production site which manufactures the Brands at Notre Dame de Bondeville, France (“the Site”). The Site would transfer to Aspen during the fourth quarter of Aspen’s 2014 financial year. (collectively “the Proposed Transaction”). The conclusion of the Proposed Transaction will be subject to GSK’s acceptance of the offer, consultation with affected GSK employees, certain regulatory approvals and approval by Aspen’s shareholders. Accordingly shareholders are advised to exercise caution when dealing in the Company’s securities until a further announcement in this regard is made. Durban 18 June 2013 Sponsor Investec Bank Limited Date: 18/06/2013 01:00:00 Produced by the JSE SENS Department. The SENS service is an information dissemination service administered by the JSE Limited ('JSE'). The JSE does not, whether expressly, tacitly or implicitly, represent, warrant or in any way guarantee the truth, accuracy or completeness of the information published on SENS. The JSE, their officers, employees and agents accept no liability for (or in respect of) any direct, indirect, incidental or consequential loss or damage of any kind or nature, howsoever arising, from the use of SENS or the use of, or reliance on, information disseminated through SENS.