Change statement and notice of Annual General Meeting ASPEN PHARMACARE HOLDINGS LIMITED (Incorporated in the Republic of South Africa) Registration number 1985/0002935/06 Share code: APN ISIN: ZAE000066692 (“Aspen” or “the Company”) CHANGE STATEMENT AND NOTICE OF ANNUAL GENERAL MEETING Shareholders are advised that the Annual Report for the year ended 30 June 2012 was posted on 5 November 2012. Shareholders are advised that the values for tangible asset capital expenditure commitments disclosed under note A of the Group supplementary information as published in the preliminary results released on SENS 12 September 2012 were understated as a result of an omission identified during the completion of the final annual report process in one of Aspen’s subsidiary companies. “Contracted and authorised tangible assets commitments” is greater by R77m with a revised total of R158.8m and “Authorised but not contracted tangible assets commitments” is greater by R111.4m with a revised total of R456.4m. The understatements did not in any way affect the earnings per share, headline earnings per share or the normalised diluted headline earnings per share from continuing operations, adjusted for transaction and restructure costs, the statement of financial position and the statement of cash flow as published in the preliminary results released on SENS 12 September 2012. The annual financial statements were audited by PricewaterhouseCoopers Inc. Their unqualified report is available for inspect at the Company’s registered office. NOTICE OF ANNUAL GENERAL MEETING Notice is hereby given that the annual general meeting of shareholders of Aspen will be held on Tuesday, 4 December 2012 at 09:00 at Building 1, Healthcare Park, Woodlands Drive, Woodmead to transact the business stated in the notice of annual general meeting, which notice forms part of the annual report. Durban 5 November 2012 Sponsor: Investec Bank Limited Date: 05/11/2012 01:00:00 Produced by the JSE SENS Department. The SENS service is an information dissemination service administered by the JSE Limited ('JSE'). The JSE does not, whether expressly, tacitly or implicitly, represent, warrant or in any way guarantee the truth, accuracy or completeness of the information published on SENS. The JSE, their officers, employees and agents accept no liability for (or in respect of) any direct, indirect, incidental or consequential loss or damage of any kind or nature, howsoever arising, from the use of SENS or the use of, or reliance on, information disseminated through SENS.