Disposal of Ascendis Pharma – Closing of Austell Pharma Disposal Ascendis Health Limited (Registration number 2008/005856/06) (Incorporated in the Republic of South Africa) Share code: ASC ISIN: ZAE000185005 (“Ascendis Health” or “the Company”) DISPOSAL OF ASCENDIS PHARMA – CLOSING OF AUSTELL PHARMA DISPOSAL Shareholders are referred to the various announcements relating to the proposed disposal by Ascendis Health SA Holdings Proprietary Limited, a wholly-owned subsidiary of Ascendis Health, of its direct and indirect interests in the entities through which the business known as “Ascendis Pharma” operates to Austell Pharmaceuticals Proprietary Limited, for a base purchase consideration of R432 million (the “Austell Pharma Disposal”). Shareholders are hereby advised that Austell Pharma Disposal has become unconditional and has closed today, 31 October 2022. The closing of the Austell Pharma Disposal is a key milestone towards creating a sustainable capital structure for the Company. The proceeds will be applied to discharge the majority of the outstanding debt and will enable the Company to re-focus its attention on the operations of its remaining businesses and the various strategic initiatives that are currently underway. 31 October 2022 Johannesburg Sponsor Valeo Capital (Pty) Limited Date: 31-10-2022 04:20:00 Produced by the JSE SENS Department. The SENS service is an information dissemination service administered by the JSE Limited ('JSE'). The JSE does not, whether expressly, tacitly or implicitly, represent, warrant or in any way guarantee the truth, accuracy or completeness of the information published on SENS. The JSE, their officers, employees and agents accept no liability for (or in respect of) any direct, indirect, incidental or consequential loss or damage of any kind or nature, howsoever arising, from the use of SENS or the use of, or reliance on, information disseminated through SENS.