Trading Statement Cilo Cybin Holdings Limited Incorporated in the Republic of South Africa (Registration number 2022/320351/06) Share code: CCC ISIN: ZAE000310397 ("Cilo Cybin" or "the Company") TRADING STATEMENT In accordance with paragraph 3.4(b) of the JSE Limited Listings Requirements, companies are required to publish a trading statement as soon as they are satisfied that a reasonable degree of certainty exists that the financial results for the period to be reported on will differ by 20% or more from the financial results for the previous corresponding period. Shareholders are advised that Cilo Cybin is in the process of finalising its results for the year ended 31 March 2025 and anticipates that it will report basic loss per share of between 0.8 cents and 0.9 cents, compared to the basic earnings per share of 0.51 cents for the previous corresponding period, which represents an expected decrease in excess of 100%. Cilo Cybin anticipates that it will report headline loss per share of between 0.8 cents and 0.9 cents compared to the headline earnings per share of 0.51 cents for the previous corresponding period, which represents an expected decrease in excess of 100%. The board of directors of Cilo Cybin hereby reminds Shareholders that, on 23 December 2024, the Company entered into a Share Purchase Agreement with the shareholders of Cilo Cybin Pharmaceutical Proprietary Limited ("CC Pharmaceutical"), in terms of which the Company will acquire 100% of the issued shares in CC Pharmaceutical for an aggregate consideration of R845 million. The purchase consideration will be settled through the issue of Cilo Cybin shares. In line with the acquisition of CC Pharmaceutical as a viable asset, the Company has incurred substantial once-off acquisition-related costs. These include, but are not limited to, fees for independent fair and reasonable assessments, corporate advisory, legal advisory, accounting, and tax advisory services. These non-recurring costs have been the primary contributor to the marginal loss reported by Cilo Cybin for the period under review. The financial information on which this trading update is based has not been reviewed or reported on by the company`s auditors. The annual results for the year ended 31 March 2025 will be released on SENS on or about Friday 27 June 2025. Johannesburg 24 June 2025 Sponsor Merchantec Capital Date: 24-06-2025 02:51:00 Produced by the JSE SENS Department. The SENS service is an information dissemination service administered by the JSE Limited ('JSE'). The JSE does not, whether expressly, tacitly or implicitly, represent, warrant or in any way guarantee the truth, accuracy or completeness of the information published on SENS. The JSE, their officers, employees and agents accept no liability for (or in respect of) any direct, indirect, incidental or consequential loss or damage of any kind or nature, howsoever arising, from the use of SENS or the use of, or reliance on, information disseminated through SENS.