Index Constituent Change - SYGH SYGNIA ITRIX COLLECTIVE INVESTMENT SCHEME Sygnia Itrix Solactive Healthcare 150 ETF JSE Code: SYGH ISIN: ZAE000300521 A portfolio in the Sygnia Itrix Collective Investment Scheme in Securities, registered as such in terms of the Collective Investment Schemes Control Act, 45 of 2002. INDEX CONSTITUENT CHANGE - SYGH In terms of section 19.28 of the JSE Limited Listings Requirements, notice is hereby given to investors of the above ETF securities that the following changes in the constituents of the underlying index in the table below is effective from 05 November 2021. The following constituents have been removed from SYGH: ISIN Share Previous New Weight Weight US0234361089 AMEDISYS INC 0.07% 0.00% CHINA EVERGRANDE NEW ENERGY HK0000264595 0.02% 0.00% VEHICLE GROUP LTD US67181A1079 OAK STREET HEALTH INC 0.09% 0.00% FR0000184798 ORPEA 0.09% 0.00% The following constituents have been added to SYGH: ISIN Share Previous New Weight Weight US00434H1086 ACCELERON PHARMA INC 0.00% 0.12% VGG111961055 BIOHAVEN PHARMACEUTICAL HOLD 0.00% 0.11% SE0000202624 GETINGE AB CLASS B 0.00% 0.12% US37611X1000 GINKGO BIOWORKS HOLDINGS INC 0.00% 0.23% US52490G1022 LEGEND BIOTECH CORP 0.03% 0.09% The above gave affect to changes in the index constituent weights. The portfolio composition file can be viewed at: www.sygnia.co.za/etfs/etf-and-etn-fund-range. 05 November 2021 Manager Sygnia Itrix (RF) Pty Limited Sponsor Vunani Date: 05-11-2021 12:00:00 Produced by the JSE SENS Department. The SENS service is an information dissemination service administered by the JSE Limited ('JSE'). The JSE does not, whether expressly, tacitly or implicitly, represent, warrant or in any way guarantee the truth, accuracy or completeness of the information published on SENS. The JSE, their officers, employees and agents accept no liability for (or in respect of) any direct, indirect, incidental or consequential loss or damage of any kind or nature, howsoever arising, from the use of SENS or the use of, or reliance on, information disseminated through SENS.