Aspen Statement on Manufacture and Supply of COVID-19 Vaccines ASPEN PHARMACARE HOLDINGS LIMITED (Incorporated in the Republic of South Africa) (“Aspen Holdings”) Registration number: 1985/002935/06 Share code: APN ISIN: ZAE000066692 LEI: 635400ZYSN1IRD5QWQ94 and its subsidiaries (collectively “Aspen” or “the Group”) ASPEN STATEMENT ON MANUFACTURE AND SUPPLY OF COVID-19 VACCINES Aspen was extremely disappointed to learn over the past weekend that specific batches of the Johnson & Johnson COVID-19 vaccine manufactured at our Gqeberha production site and designated for the South African market have to be destroyed due to the Good Manufacturing Practice risk of isolated material in the drug substance supplied to Aspen by Johnson & Johnson from their contract manufacturing partner in the USA, Emergent. The batches manufactured had been retained in storage awaiting the outcome of the US FDA assessment of Emergent. This is not only a setback to both the Aspen and Johnson & Johnson teams who have worked tirelessly to ensure the manufacture of these batches, but more importantly, has the potential to negatively impact the vaccine rollout across South Africa and Africa. To mitigate the potential risk to vaccine access, and in substitution of the volumes lost, the following actions have been undertaken: - Within days, Johnson & Johnson will provide 300 000 doses of the vaccine for South African teachers - Within a week, Aspen expects to release Johnson & Johnson vaccines manufactured from drug substance that has not been impacted by the Emergent contamination - Over the next few weeks, Johnson & Johnson will be delivering substantial quantities of compliant finished vaccines to South Africa to replace the lost stock thereby ensuring the momentum in the South African vaccine initiative is maintained - Aspen has further doses of the vaccine in production that will become available in July - These Johnson & Johnson vaccines released by Aspen will support the vaccination programmes in South Africa and elsewhere in Africa. We thank the Aspen teams for their exemplary response in managing this setback and our partner, Johnson & Johnson, who through their actions, have not only assisted in capacitating the African continent, but at this challenging time have stepped up again to ensure that we are able to maintain the momentum needed to give our continent access to lifesaving vaccines. Durban 14 June 2021 Sponsor Investec Bank Limited Date: 14-06-2021 02:25:00 Supplied by www.sharenet.co.za Produced by the JSE SENS Department. The SENS service is an information dissemination service administered by the JSE Limited ('JSE'). The JSE does not, whether expressly, tacitly or implicitly, represent, warrant or in any way guarantee the truth, accuracy or completeness of the information published on SENS. The JSE, their officers, employees and agents accept no liability for (or in respect of) any direct, indirect, incidental or consequential loss or damage of any kind or nature, howsoever arising, from the use of SENS or the use of, or reliance on, information disseminated through SENS.