Notification of a change in indirect beneficial interests of directors Ascendis Health Limited (Registration number 2008/005856/06) (Incorporated in the Republic of South Africa) Share code: ASC ISIN: ZAE000185005 (“Ascendis” or “the Company”) Notification of a change in indirect beneficial interests of directors In terms of paragraph 3.64(h) of the JSE Listings Requirements, shareholders are hereby notified of the following internal restructurings undertaken by Coast2Coast Capital Proprietary Limited (“C2C”), the latter of which will result in a minimal dilution to Mr. Gary Shayne’s and Mr. Crispian Dillon’s indirect exposure to C2C’s portfolio investments, one of which comprises a 28.96% interest in Ascendis shares: - an internal restructuring within C2C of Mr. Crispian Dillon’s ownership from subsidiary level to holding company level (“the C2C Restructuring”); and - an allocation of incentives to C2C staff members, in terms of which C2C staff members acquire an interest in C2C (and therefore exposure to Ascendis shares, amongst other investments held by C2C) (“the C2C Incentives”). The C2C Restructuring will not, in the absence of the C2C Incentives, result in any change in Mr. Crispian Dillion’s or Mr Gary Shayne’s effective interest in C2C and therefore in Ascendis shares. The implementation of the C2C Incentives will result in a minimal dilution of Mr. Gary Shayne’s and Mr. Crispian Dillon’s interest in C2C (and therefore, their indirect effective interest in Ascendis shares), as follows: - Mr. Crispian Dillon’s indirect interest in Ascendis shares will be diluted by 0.12% (i.e. from 4.35% to 4.23%); and - Mr Gary Shayne’s indirect interest in Ascendis shares will be diluted by 0.69% (i.e. from 24.67% to 23.98%). There will be no movement or dealing in Ascendis shares by C2C as a result of the implementation of the C2C Restructuring and/or the C2C Incentives and therefore the aggregate exposure by C2C to Ascendis will remain unchanged at 28.96%. Bryanston 18 April 2018 Sponsor Questco Corporate Advisory Proprietary Limited Date: 18/04/2018 12:01:00 Produced by the JSE SENS Department. The SENS service is an information dissemination service administered by the JSE Limited ('JSE'). The JSE does not, whether expressly, tacitly or implicitly, represent, warrant or in any way guarantee the truth, accuracy or completeness of the information published on SENS. The JSE, their officers, employees and agents accept no liability for (or in respect of) any direct, indirect, incidental or consequential loss or damage of any kind or nature, howsoever arising, from the use of SENS or the use of, or reliance on, information disseminated through SENS.