Dealings in securities by directors ASCENDIS HEALTH LIMITED (Incorporated in the Republic of South Africa) (Registration number 2008/005856/06) ISIN: ZAE000185005 Share code: ASC (“Ascendis”) Dealings in securities by directors In terms of paragraphs 3.63 to 3.74 of the JSE Listings Requirements, the following information, relating to dealings in securities by directors, is disclosed: Directors: Gary Shayne and Crispian Dillon. Nature of the transactions: Coast2Coast Capital Proprietary Limited (“C2C”) (in which Gary Shayne holds an 85% indirect interest and Crispian Dillon holds a 15% indirect interest), is required to redeem two existing debentures, entered into on 26 February 2016 and 19 August 2016 respectively, and each issued by an indirect subsidiary of C2C, by way of a settlement of Ascendis shares. The Ascendis shares are thus transferred to effect the redemption of the debentures, at a price per share determined using the pre-agreed pricing mechanism for each debenture. Furthermore, C2C will indirectly purchase shares in terms of a put and call option agreement entered into on 21 May 2015. C2C will purchase the Ascendis shares at the price determined per the option agreement. Date of transaction: 29 September 2017 Class of shares: Ordinary shares Number of shares 689,783 Price per share R27.53 Value R18,989,725.99 Nature of transactions: Sale, off market Number of shares 5,236,701 Price per share R23.43 Value R122,695,904.43 Nature of transactions: Sale, off market Number of shares 266,667 Price per share R21.00 Value R5,600,007.00 Nature of transactions: Purchase, off market Extent of interest: Indirect beneficial (through C2C, in which Gary Shayne has a 85% indirect beneficial interest and Crispian Dillon has a 15% indirect beneficial interest). Written clearance obtained: Clearance was obtained from the Chairman. 29 September 2017 Johannesburg Sponsor Investec Bank Limited Date: 29/09/2017 10:50:00 Produced by the JSE SENS Department. The SENS service is an information dissemination service administered by the JSE Limited ('JSE'). The JSE does not, whether expressly, tacitly or implicitly, represent, warrant or in any way guarantee the truth, accuracy or completeness of the information published on SENS. The JSE, their officers, employees and agents accept no liability for (or in respect of) any direct, indirect, incidental or consequential loss or damage of any kind or nature, howsoever arising, from the use of SENS or the use of, or reliance on, information disseminated through SENS.