Dealings in securities by directors ASCENDIS HEALTH LIMITED (Incorporated in the Republic of South Africa) (Registration number 2008/005856/06) ISIN: ZAE000185005 Share code: ASC (“Ascendis”) Dealings in securities by directors In terms of paragraphs 3.63 to 3.74 of the JSE Listings Requirements, the following information, relating to dealings in securities by directors, is disclosed: Directors: Gary Shayne and Crispian Dillon. Nature of the transaction: Coast2Coast Capital Proprietary Limited (“C2C”) (in which Gary Shayne holds an 85% indirect interest and Crispian Dillon holds a 15% indirect interest), has notified the vendors of Akacia Healthcare Holdings Proprietary Limited (“Akacia”) on 24 April 2017 of its intention to indirectly purchase shares in terms of a put and call option agreement entered into on 19 November 2015 with various vendors of Akacia as per the SENS announcement released on 19 November 2015 (“Option Agreement”). C2C will simultaneously transfer the shares purchased via the Option Agreement to C2C staff (“C2C Staff Shares”). This purchase and subsequent transfer will therefore not effect a change in the overall C2C shareholding in Ascendis. Number of shares: 999,190 Price per share purchased in terms R26.08 of Option Agreement: Price per share transferred in terms R22.25 of C2C Staff Shares : Value in terms of Option R26,058,875.20 Agreement: Value in terms of C2C Staff R22,231,977.50 Shares: Date of transaction: 24 April 2017 Class of shares: Ordinary shares Nature of transaction: Purchase off market in terms of Option Agreement and sale off market in terms of C2C Staff Shares Extent of interest: Indirect beneficial (through C2C, in which Gary Shayne has an 85% indirect beneficial interest and Crispian Dillon has a 15% indirect beneficial interest). Written clearance obtained: Clearance was obtained from the Chairman. Directors: Gary Shayne and Crispian Dillon. Nature of the transaction: Coast2Coast Capital Proprietary Limited (“C2C”) (in which Gary Shayne holds an 85% indirect interest and Crispian Dillon holds a 15% indirect interest), disposed of 2,666,667 shares to WDB Investment Holdings (Pty) Limited, a strategic long term investor, and disposed of a total of 1,800,000 shares to various other investors. The sale of shares will result in a c.3.5% decrease in C2C’s overall shareholding in Ascendis as it continues to hold Ascendis ordinary shares to the value of c. R2.8 billion at the current trading price. Number of shares: 4,466,667 Price per share: R22.50 Value: R100,500,007.50 Date of transaction: 24 April 2017 Class of shares: Ordinary shares Nature of transaction: Sale, off market Extent of interest: Indirect beneficial (through C2C, in which Gary Shayne has an 85% indirect beneficial interest and Crispian Dillon has a 15% indirect beneficial interest). Written clearance obtained: Clearance was obtained from the Chairman. 25 April 2017 Johannesburg Sponsor Investec Bank Limited Date: 25/04/2017 10:10:00 Produced by the JSE SENS Department. The SENS service is an information dissemination service administered by the JSE Limited ('JSE'). The JSE does not, whether expressly, tacitly or implicitly, represent, warrant or in any way guarantee the truth, accuracy or completeness of the information published on SENS. The JSE, their officers, employees and agents accept no liability for (or in respect of) any direct, indirect, incidental or consequential loss or damage of any kind or nature, howsoever arising, from the use of SENS or the use of, or reliance on, information disseminated through SENS.