Trading Statement ASCENDIS HEALTH LIMITED (Incorporated in the Republic of South Africa) (Registration number 2008/005856/06) Share code: ASC ISIN: ZAE000185005 (“Ascendis” or “the Company”) TRADING STATEMENT In terms of paragraph 3.4(b) of the JSE Limited’s Listings Requirements, Ascendis shareholders are hereby advised that the Company’s financial results for the six months ended 31 December 2016 are expected to be more than a 20% change from the previous corresponding period. The table below illustrates the ranges anticipated against the comparative period: 6 months ended 6 months ended % increase/ 31 December 31 December (decrease) 2016 2015 Normalised Headline Earnings R298m – R315m R151m 97% – 109% Normalised Headline Earnings per share 72 – 76 cents 56 cents 29% – 36% (“NHEPS”) Basic Earnings R166m – R178m R132m 26% – 35% Basic Earnings per share (“EPS”) 40 – 43 cents 49 cents (18)% – (12)% Headline Earnings R166m – R178m R131m 27% - 36% Headline Earnings per share (“HEPS”) 40 – 43 cents 49 cents (18)% - (12)% Notes: 1. Normalised headline earnings and NHEPS comprise basic earnings adjusted for specific non- trading items and once-off costs. Once off costs for the 6 months ended 31 December 2016 amount to c.R92m, primarily relating to transaction costs, finance and hedging costs for the purchase of Remedica and Scitec as announced on SENS on 26 August 2016 (“Acquisitions”). Accordingly the contributions from the Acquisitions are not consolidated for the full period. 2. The “per share” measures reflect a lower percentage increase than the earnings numbers due to the change in weighted average number of shares from c. 270m to 414m due to additional shares issued by Ascendis during the course of the six month period ended 31 December 2016 in connection with the Acquisitions. The financial information on which this trading statement is based has not been reviewed or reported on by the Company’s auditors. Shareholders are advised that the results for the six months ended 31 December 2016 are scheduled to be released on SENS on 8 March 2017 and presented in Cape Town on 8 March 2017 and Johannesburg on 9 March 2017. 23 February 2017 Johannesburg Sponsor Investec Bank Limited Date: 23/02/2017 11:00:00 Produced by the JSE SENS Department. The SENS service is an information dissemination service administered by the JSE Limited ('JSE'). The JSE does not, whether expressly, tacitly or implicitly, represent, warrant or in any way guarantee the truth, accuracy or completeness of the information published on SENS. The JSE, their officers, employees and agents accept no liability for (or in respect of) any direct, indirect, incidental or consequential loss or damage of any kind or nature, howsoever arising, from the use of SENS or the use of, or reliance on, information disseminated through SENS.