Notification in terms of section 122(3) of the Companies Act and section 3.83(b) of the JSE Listings Requirements ASCENDIS HEALTH LIMITED (Incorporated in the Republic of South Africa) (Registration number 2008/005856/06) ISIN: ZAE000185005 JSE share code: ASC (“Ascendis” or “the Company”) NOTIFICATION IN TERMS OF SECTION 122(3) OF THE COMPANIES ACT AND SECTION 3.83(b) OF THE JSE LISTINGS REQUIREMENTS In accordance with section 122(3)(b) of the Companies Act, 71 of 2008 ("the Act"), and section 3.83(b) of the JSE Listing Requirements, holders of ordinary shares in Ascendis are advised that, following Kefolile Health Investments Proprietary Limited’s (“Kefolile”) participation in the Ascendis vendor consideration placement, which was announced on the Stock Exchange News Service of the JSE Limited on 30 June 2016, Kefolile’s beneficial interests in the securities of the Company amount to 5.3% of the total number of shares in issue. Ascendis hereby confirms that it has received the required notice from Kefolile in terms of Section 122(1) of the Act. As required in terms of section 122(3) (a) of the Act, Ascendis has filed the required notice with the Takeover Regulation Panel. Johannesburg 30 August 2016 Sponsor: Investec Bank Limited Date: 30/08/2016 12:25:00 Produced by the JSE SENS Department. The SENS service is an information dissemination service administered by the JSE Limited ('JSE'). The JSE does not, whether expressly, tacitly or implicitly, represent, warrant or in any way guarantee the truth, accuracy or completeness of the information published on SENS. The JSE, their officers, employees and agents accept no liability for (or in respect of) any direct, indirect, incidental or consequential loss or damage of any kind or nature, howsoever arising, from the use of SENS or the use of, or reliance on, information disseminated through SENS.