Fulfillment of conditions and renewal of cautionary ASCENDIS HEALTH LIMITED (Incorporated in the Republic of South Africa) (Registration number 2008/005856/06) ISIN: ZAE000185005 JSE share code: ASC (“Ascendis” or “the Company”) FULFILMENT OF OUTSTANDING CONDITIONS PRECEDENT REGARDING THE ACQUISITION BY ASCENDIS OF AKACIA HEALTHCARE HOLDINGS PROPRIETARY LIMITED (“AKACIA”) AND RENEWAL OF CAUTIONARY Ascendis shareholders are referred to the SENS announcement dated 19 November 2015 advising of Ascendis entering into an agreement with the shareholders of Akacia to acquire 100% of the pharmaceutical business of Akacia (“the Acquisition”), subject to the fulfilment of certain conditions precedent. The Company’s board of directors is pleased to announce that all outstanding conditions precedents have been fulfilled which accordingly renders the Acquisition unconditional. Shareholders are advised that the cautionary announcement released on SENS on 14 March 2016 is still in effect as negotiations are ongoing and accordingly shareholders must continue to exercise caution when dealing in the Company’s securities until a full announcement is made. 13 April 2016 Johannesburg Arranger and Financial Advisor Coast2Coast Capital Proprietary Limited Sponsor Investec Bank Limited Date: 13/04/2016 10:15:00 Produced by the JSE SENS Department. The SENS service is an information dissemination service administered by the JSE Limited ('JSE'). The JSE does not, whether expressly, tacitly or implicitly, represent, warrant or in any way guarantee the truth, accuracy or completeness of the information published on SENS. The JSE, their officers, employees and agents accept no liability for (or in respect of) any direct, indirect, incidental or consequential loss or damage of any kind or nature, howsoever arising, from the use of SENS or the use of, or reliance on, information disseminated through SENS.