Dealings in securities by directors ASCENDIS HEALTH LIMITED (Incorporated in the Republic of South Africa) (Registration number 2008/005856/06) ISIN: ZAE000185005 Share code: ASC (“Ascendis”) Dealings in securities by directors In terms of paragraphs 3.63 to 3.65 of the JSE Limited (“the JSE”) Listings Requirements ("the Listings Requirements"), the following information, relating to dealings in securities by directors, is disclosed: Directors: Gary Shayne and Crispian Dillon. Nature of the transaction: Ascendis has entered into an agreement (which remains subject to certain conditions precedent) to purchase a company (“Acquired Company”). The transaction size is approximately 3.7% of the Ascendis market capitalisation, which is below a category two transaction in terms of the Listings Requirements. Gane Holdings Proprietary Limited (“Gane Holdings”) (in which Gary Shayne has a 85% indirect beneficial interest and Crispian Dillon has a 15% indirect beneficial interest), which does not form part of the Ascendis group of companies, has entered into a separate agreement (“Option Agreement”) with the disposing shareholders of the Acquired Company (“Disposing Shareholders”), dated 14 December 2015, whereby Gane Holdings has granted the Disposing Shareholders a put option and the Disposing Shareholders have granted Gane Holdings a reciprocal call option in respect of the Ascendis shares that will be issued to the Disposing Shareholders as part settlement of the purchase consideration for the Acquired Company. Clearance in terms of paragraph 3.66 of the Listings Requirements has been obtained from the Chairman of the Board. No fees are payable by Ascendis to Gane Holdings for this agreement and there are no financial implications for Ascendis as a result of this agreement. Number of Option Shares: Maximum of 5,000,000 Option Exercise Date: The sooner of the approval of the Acquired Company’s financial statements for the financial year end 30 June 2018 and 31 December 2018 Strike price: Volume weighted average price for the 30 days preceding the Option Exercise Date Deemed transaction value: Maximum of R190,000,000 Extent of interest: Indirect beneficial, through Gane Holdings, in which Gary Shayne has an 85% indirect beneficial interest and Crispian Dillon has a 15% indirect beneficial interest. 17 December 2015 Johannesburg Sponsor: Investec Bank Limited Date: 17/12/2015 02:00:00 Produced by the JSE SENS Department. The SENS service is an information dissemination service administered by the JSE Limited ('JSE'). The JSE does not, whether expressly, tacitly or implicitly, represent, warrant or in any way guarantee the truth, accuracy or completeness of the information published on SENS. The JSE, their officers, employees and agents accept no liability for (or in respect of) any direct, indirect, incidental or consequential loss or damage of any kind or nature, howsoever arising, from the use of SENS or the use of, or reliance on, information disseminated through SENS.