Renewal of Cautionary ASPEN PHARMACARE HOLDINGS LIMITED (Incorporated in the Republic of South Africa) Registration number 1985/0002935/06 Share code: APN ISIN: ZAE000066692 ("Aspen" or "the Company") Renewal of Cautionary Announcement- Discussions with GSK Shareholders are referred to the cautionary announcement released by Aspen on 18 June 2013 (and subsequent renewals) in which shareholders were advised of discussions between Aspen and GlaxoSmithKline plc (“GSK”) in respect of a possible transaction in terms whereof: • Aspen Global Incorporated, a wholly owned subsidiary of Aspen, will acquire from GSK the Arixtra and Fraxiparine/Fraxodi brands (“the Brands”) and business worldwide, except in China, Pakistan and India; and • Aspen will acquire from GSK a specialised sterile production site which manufactures the Brands at Notre Dame de Bondeville, France (“the Site”); (collectively “the Proposed Transaction”); and • Aspen’s offer to GSK in respect of the Proposed Transaction is approximately GBP 700 million of which approximately GBP 100 million is for inventory. Shareholders are advised that discussions regarding the Proposed Transaction remain ongoing and may have a material effect on the price of Aspen’s securities if successfully concluded and accordingly shareholders are advised to continue exercising caution when dealing in Aspen’s securities. Durban 5 September 2013 Sponsor: Investec Bank Limited Date: 05/09/2013 04:00:00 Produced by the JSE SENS Department. The SENS service is an information dissemination service administered by the JSE Limited ('JSE'). The JSE does not, whether expressly, tacitly or implicitly, represent, warrant or in any way guarantee the truth, accuracy or completeness of the information published on SENS. The JSE, their officers, employees and agents accept no liability for (or in respect of) any direct, indirect, incidental or consequential loss or damage of any kind or nature, howsoever arising, from the use of SENS or the use of, or reliance on, information disseminated through SENS.